Flagix (Metronidazol) 500
Attributes
| Category | Generic Name | Brand |
|---|---|---|
| Antiprotozoal | Metronidazol | Flagix |
| Dosage Form | Dosage | Packing |
| F.C Tablet | 500 mg | 20 |
Flagix (Metronidazol) 500
 |
General Description | – |
|
Side Effects | Appetite loss, Candidiasis, Diarrhea, Dizziness, Headache, Nausea, Vomiting, Ataxia, Dark urine, Disulfiram-type reaction with ethanol, Furry tongue, Hypersensitivity, Neutropenia, Metallic taste, Neuropathy, Pancreatitis, Seizures, Thrombophlebitis, Xerostomia, Encephalopathy, Aseptic meningitis, Optic neuropathy, Stevens-Johnson syndrome, Toxic epidermal necrolysis, Decreased libido |
|
Direction of use | Adult: 1) Anaerobic Bacterial Infections Maintenance dose: 7.5 mg/kg (over 1 h) q6hr x 7-10 days (or 2-3 weeks if severe) 2) Prevention following sexual assault 2 g PO as a single dose; 3-drug regimen that also includes ceftriaxone or cefixime, plus azithromycin or doxycycline (CDC STD guidelines, 2010) 3) Bacterial Vaginosis Non-pregnant women • 500 mg PO q12hr x 7 days, OR • 2 g PO q Day single dose Pregnant women • 500 mg PO q12hr x 7 days, OR • 250 mg PO q8hr x 7 days 4) Colorectal Surgical Infection Prophylaxis; start after mechanical bowel preparation the afternoon and evening before surgery 1 g PO q6-8hr for 3 doses 5) Trichomoniasis 250 mg PO q8hr for 7 days 6) Amebiasis 500-750 mg PO q8hr for 5-10 days 7) Giardiasis (Off-label) 500 mg PO q12hr for 5-7 days 8) Gardnerella Infection Immediate release: 500 mg PO q12hr 9) Helicobacter Pylori Infection (Off-label) 250-500 mg PO q6hr in combination with tetracycline (500 mg) and bismuth subsalicylate (525 mg) x 14 days 10) Non-gonococcal Urethritis (Off-label) 2 g PO q Day single dose with erythromycin (500 mg q6hr) or erythromycin ethyl succinate (800 mg q6hr) x 7 days 11) Pelvic Inflammatory Disease (Off-label) 500 mg PO q12hr for 14 days in conjunction with ofloxacin or levofloxacin Pediatric: 1) Anaerobic Infection Infants and Children 30 mg/kg/day divided q6hr; not to exceed 4 g/day 2) Clostridium Difficile Colitis 30 mg/kg/day divided q6hr for 7-10 days (American Academy of Pediatrics) 3) Amebiasis 35-50 mg/kg divided q8hr for 10 days 4) Giardiasis 15 mg/kg/day divided q8hr for 5 days 5) Trichomoniasis < 45 kg body weight: 15 mg/kg/day divided q8hr for 7 days; not to exceed 2 g/day 6) Helicobacter Pylori-Associated Peptic Ulcer Disease (Off-label) With amoxicillin and bismuth subsalicylate: 15-20 mg/kg/day divided q12hr for 4 weeks |
|
Warnings | Hypersensitivity to metronidazole or other nitroimidazoles (although cautious desensitization has been applied) Pregnancy, 1st trimester (controversial) Use of disulfiram within past 2 weeks; use of alcohol during therapy or within 3 days of discontinuing therapy |
|
Catalog | Flagix (Metronidazol) 500 Catalog |