Flagix (Metronidazol) 250

Flagix (Metronidazol) 250

Attributes

Category Generic Name Brand
Antiprotozoal Metronidazol Flagix
Dosage Form Dosage Packing
F.C Tablet 250 mg 100

Flagix (Metronidazol) 250


General Description
Side Effects Appetite loss, Candidiasis, Diarrhea, Dizziness, Headache, Nausea, Vomiting, Ataxia, Dark urine, Disulfiram-type reaction with ethanol, Furry tongue, Hypersensitivity, Neutropenia, Metallic taste, Neuropathy, Pancreatitis, Seizures, Thrombophlebitis, Xerostomia, Encephalopathy, Aseptic meningitis, Optic neuropathy, Stevens-Johnson syndrome, Toxic epidermal necrolysis, Decreased libido
Direction of use Adult: 1) Anaerobic Bacterial Infections Maintenance dose: 7.5 mg/kg (over 1 h) q6hr x 7-10 days (or 2-3 weeks if severe) 2) Prevention following sexual assault 2 g PO as a single dose; 3-drug regimen that also includes ceftriaxone or cefixime, plus azithromycin or doxycycline (CDC STD guidelines, 2010) 3) Bacterial Vaginosis Non-pregnant women • 500 mg PO q12hr x 7 days, OR • 2 g PO q Day single dose Pregnant women • 500 mg PO q12hr x 7 days, OR • 250 mg PO q8hr x 7 days 4) Colorectal Surgical Infection Prophylaxis; start after mechanical bowel preparation the afternoon and evening before surgery 1 g PO q6-8hr for 3 doses 5) Trichomoniasis 250 mg PO q8hr for 7 days 6) Amebiasis 500-750 mg PO q8hr for 5-10 days 7) Giardiasis (Off-label) 500 mg PO q12hr for 5-7 days 8) Gardnerella Infection Immediate release: 500 mg PO q12hr 9) Helicobacter Pylori Infection (Off-label) 250-500 mg PO q6hr in combination with tetracycline (500 mg) and bismuth subsalicylate (525 mg) x 14 days 10) Non-gonococcal Urethritis (Off-label) 2 g PO q Day single dose with erythromycin (500 mg q6hr) or erythromycin ethyl succinate (800 mg q6hr) x 7 days 11) Pelvic Inflammatory Disease (Off-label) 500 mg PO q12hr for 14 days in conjunction with ofloxacin or levofloxacin Pediatric: 1) Anaerobic Infection Infants and Children 30 mg/kg/day divided q6hr; not to exceed 4 g/day 2) Clostridium Difficile Colitis 30 mg/kg/day divided q6hr for 7-10 days (American Academy of Pediatrics) 3) Amebiasis 35-50 mg/kg divided q8hr for 10 days 4) Giardiasis 15 mg/kg/day divided q8hr for 5 days 5) Trichomoniasis < 45 kg body weight: 15 mg/kg/day divided q8hr for 7 days; not to exceed 2 g/day 6) Helicobacter Pylori-Associated Peptic Ulcer Disease (Off-label) With amoxicillin and bismuth subsalicylate: 15-20 mg/kg/day divided q12hr for 4 weeks
Warnings Hypersensitivity to metronidazole or other nitroimidazoles (although cautious desensitization has been applied) Pregnancy, 1st trimester (controversial) Use of disulfiram within past 2 weeks; use of alcohol during therapy or within 3 days of discontinuing therapy
Catalog Flagix (Metronidazol) 250 Catalog
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